Chapter 2458 【2458】It's the Disease

Zhu Xing's mother struggled to recall what the attending doctor said. It was really difficult for her, and her brain was so tired that it was about to go on strike.

The doctor could only help the family remember the key points related to the child's life word by word: "Zhu Xing's heart has expanded to resemble a ball. In his condition, the condition can only get worse and worse. In this case we have to consider giving him a heart transplant."

The heart is dilated, which at first sounds like the dilated cardiomyopathy we talked about before. Dilated cardiomyopathy is a type of cardiomyopathy.

Cardiomyopathy is divided into primary and specific (secondary), and the classification concept of primary and secondary is consistent with other diseases.

Dilated cardiomyopathy is primary, but the classification of primary cardiomyopathy is much more than dilated cardiomyopathy. Zhu Xing's dilated heart is primary cardiomyopathy, but it is not the dilated cardiomyopathy we mentioned before, but a genetic cardiomyopathy called congenital insufficiency of myocardial compaction.

This disease is relatively rare.

Why is it rare, because it either has hidden symptoms and has always existed in the patient's body without the disease, or the patient's condition is already very serious once the disease occurs. This disease is especially not found through daily physical examinations such as electrocardiograms or routine auscultations. To find out, you need to rely on more sophisticated instruments, including echocardiography, magnetic resonance CT and other means. If the patient is asymptomatic, who will go for these further examinations? There will not be any, which makes it difficult for doctors to detect it in the early stage.

What kind of disease is this disease. Since it is a genetic disease, the root cause is the dominant or recessive inheritance of human disease-causing genes. It is manifested in that many patients have family history, and problems have occurred in the patient's heart during embryonic development.

Our heart has no coronary arteries in the first month of embryonic development. At this time, the main components of the myocardium are muscle trabeculae and crypts, and the blood supply of the heart depends on the crypts. These structures belong to the non-compacted layer of the ventricular wall pathologically. During the fifth and sixth weeks of normal embryonic development, the non-densified layer will be densified to grow out of the epicardium and endocardium, and the crypts will be compressed to become the coronary artery system.

As in patients with non-compacting myocardium, myocardial compaction fails at this time point during embryonic development, leading to pathologically visible thickening of the noncompacted layer of the ventricular wall. In this way, the patient's myocardium is always mainly composed of muscle trabeculae and crypts, and the grooves are interlaced like a network like a sponge, so this disease is also called spongy cardiomyopathy.

Cavernoid cardiomyopathy can be an isolated disease with only this symptom, or it can be complicated by other cardiac malformations. In pediatrics, isolated myocardial insufficiency is the main cause.

Zhu Xing is a typical congenital isolated myocardial compaction. Not only that, his father died suddenly, and it cannot be ruled out that it was also due to this illness.

To sum up, the most damning thing about this disease is that if the lesion range is small, the patient can have a normal heart function for a long time, which confuses the patient and the doctor. When it occurs, the lesion range is very large, and the patient will develop heart failure, and then deteriorate into intractable heart failure and severe arrhythmia. Like Zhu Xing, the dilated heart becomes a ball and cannot be reversed. Like dilated cardiomyopathy, the original heart surgery can only change the heart structure but not correct the diseased myocardium. The only way to save life is heart transplantation.