Chapter 1774 Where Is the Core Technology?

This discovery simply made the entire research institute boil!

The discovery of this polymerase seems to directly verify what Parkinson and Alzheimer have in common in neurodegeneration!

However, this is not the point.

The most important thing is that Parkinson finally has a breakthrough!

Chen Cang himself didn't expect that the temptation of enzymes would be so powerful!

The polymerase, the culprit, was directly discovered.

After the discovery of polymerase, all departments started clinical research and various experimental work!

The progress of the experiment can almost be said to be advancing by leaps and bounds!

Everyone is immersed in this breakthrough-like progress!

Tedanis doesn't regret joining Chen Cang's camp now.

He believes that even Considine can't do this, and can isolate poly ADP-ribose polymerase-1!

This polymerase belongs to ribose polymerase, which exists in the mitochondria and ribose of cells, and the difficulty of separation is super high!

For a while, the news that Professor Chen isolated this polymerase spread throughout the institute!

Everyone is shocked!

Professor Chen actually has such a talent in the field of scientific research?

Creatively invented a technique called "foam separation".

For a while, Chen Cang's reputation boiled again.

However, the most important thing is not Chen Cang's reputation.

It was Boss Chen's innovative discovery, directly extracting poly ADP-ribose polymerase-1!

And the research of this enzyme on Parkinson's is also increasing day by day!

Soon, Tedanis led the team to discover that the main function of this polymerase is actually widely present in the nucleus to repair DNA!

Under normal conditions, after the polymerase detects DNA damage, it will be activated and then repaired!

However, when the circumstances of the case prevent the DNA from being repaired, the polymerase becomes overactive!

As a result, it leads to degeneration of the nervous system, which intensifies the growth of folded α-synuclein, and induces Lewy bodies again... A series of complicated processes lead to the aggravation of Parkinson's!

The discovery of Tedanis made Yang Lan's eyes shine.

Qi Kai and Yang Lan quickly started the animal experiments!

Animal experimentation is a link close to the correct answer!

The emergence of theoretical basis has made this experiment more and more exciting.

Obviously, once a conclusion is reached, it will shock the world.

In the process of research!

When Yang Lan and Qi Kai conducted animal experiments on Parkinson's rats.

More and more scary and even shocking problems were found!

The human body has a rich and complete feedback system.

The special state of Parkinson's will make the regulation of this polymerase lose the opportunity of feedback!

And again, the presence of this polymerase also aggravates the increase in folded alpha-synuclein in Parkinson's patients, further aggravating Parkinson's condition.

What a process!

Vicious circle!

That's right!

Parkinson makes polymerase unrestricted.

Polymerase aggravates folding α-synuclein, aggravating Parkinson's!

In this way, it seems to form a closed loop.

If one link is not broken, the cycle will become more serious.

a!

When Chen Cang was in the hospital, Qi Kai called Chen Cang directly to the research institute!

Pass a piece of information to Chen Cang!

"Professor Chen, look at this thing!"

Chen Cang was stunned for a moment. After he opened it and saw the title, he froze in place!

"Neurotoxicity of alpha-synuclein!"

Chen Cang quickly began to look at it.

Seeing this, Chen Cang couldn't hold it anymore!

Because Tedanese's research found that folded pathological α-synuclein aggregates are able to spread between neurons in the brain!

Moreover, this pathological α-synuclein will act like a seed, inducing normal α-synuclein, leading to degeneration of the nervous system!

After seeing this scene, Chen Cang was stunned!

Qi Kai couldn't help but said: "Now it's finally explained why the death rate of Parkinson's mice has increased!"

"Because folded alpha-synuclein is contagious!"

"And this polymerase is the most critical intermediate product!"

Tedanis said with some excitement: "As long as this polymerase is solved and reasonably inhibited, the onset of Parkinson's can be directly delayed!"

Zhang Mu shook his head: "Not only that!"

"The most important thing about Parkinson's disease is not the later treatment, but the early prevention!"

When everyone heard the sound, they immediately thought carefully!

Zhang Mu continued: "This is a vicious circle!"

"As long as there is folded pathological α-synuclein, there must be all kinds of polymerases, and again, the polymerases aggravate the folded α-synuclein!"

"In this way, the most critical thing is how to discover the folded α-synuclein as early as possible, and intervene in time through surgery and drugs!"

After Zhang Mu finished speaking, everyone immediately became excited.

yes!

In this way, it seems that they have found a good way to overcome Parkinson's as soon as possible.

Treatment is no longer the goal!

But early detection and early intervention!

"How to check the folded α-synuclein in human body?"

"Yeah, how can we find out that people have Parkinson's as early as possible?"

indeed!

Parkinson's itself is a symptomatic disease.

Only with performance can it be discovered.

Can't everyone go for a census of α-synuclein?

This is definitely not realistic!

Can Parkinson's be prevented?

Thinking of this, everyone couldn't help but sigh.

What a pity.

It is not easy to have such a breakthrough.

If it can be detected in advance, the patient will save a lot of trouble.

How can we find out in advance?

At this moment, Chen Cang's eyes suddenly lit up.

He thought of a big baby!

The new technology that I sold to Google at the beginning was also the new technology that made Chen Cang a profit of 1 billion US dollars: "brain stereotaxic technology!"

This new type of cranial stereotactic technology has a special ability: DTI technology!

That is, magnetic resonance diffusion Zhang Liang imaging!

The integrity and connectivity of the tissue structure can be observed in vivo, which is beneficial to the judgment of the damage degree and scope of the white matter fiber bundles of various diseases.

At the same time, it can also respond to subtle changes in the brain of patients with mental illness. Not only that, DTI technology can also display the direction of nerve conduction bundles in the white matter of the brain, and realize fine imaging of human central nervous fibers.

Under the guidance of DTI technology, the individual differences of patients with Parkinson's disease can be accurately displayed and positioned, and at the same time, it can be fused to perform 3D image reconstruction surgery to guide doctors to perform accurate and efficient surgery.

Chen Cang really didn't expect it!

After going around such a big circle.

The core technology is still in his own hands!

...

ps: There are too many information to check, helpless, you can’t write blindly, which means you need to take every knowledge point seriously.

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