Chapter 257 It Takes Two Nobel Prizes to Complete the Task? !

What?

Make vitamin C?

Grete was dumbfounded.

How difficult is it to determine that scurvy is due to a lack of vitamin C, and to find out? Simply put, this achievement is worth two Nobel Prizes.

In 1937, Hungarian biochemist Szent-Gyorgyi won the Nobel Prize in Physiology or Medicine for his research on vitamin C and oxidation reactions in the human body.

In the same year, British scientist Haworth won the Nobel Prize in Chemistry for determining the chemical structure of vitamin C and artificially producing vitamin C.

Archmage Carlisle, you think so highly of me T_T If I had the ability to make vitamin C with my bare hands, I wouldn’t have been struggling for more than ten years in my previous life, and I would just be a deputy chief physician!

My highest degree is a master's degree!

My major is clinical medicine, not pharmacy!

By the way, what is the path for industrial production of vitamin C... I have not forgotten this, I have never learned this at all...

Gretel descended to Igor Peak in depression. The thought of having to climb over two Nobel Prizes to complete the task made him feel so weak that he didn't even want to enter the laboratory. By the way, he has to make a magic potion to solve a problem that can be solved with a lemon every day. Is this really okay?

It's so annoying... Why don't you write a paper on the conclusion of lemon juice treatment and send it to the alchemy workshop and let them think of ways to make it into a medicine...

Grete was unhappy, so he cast a spell to summon a mount, and sat on the horse and walked. The horse summoned by magic is smarter and more intelligent than the horse that exists in nature. Even if the owner does not control it, it will not be frightened and run around or step on people. Gretel was riding his horse in a daze, and the horse moved around randomly. Unknowingly, a fishy smell hit his face.

Grete came back to his senses, looked up, and realized that he had reached the port area. Come on, let’s go to the treatment center. With this thought, Gretel turned his horse’s head in a circle, click, click, click, and soon arrived at the treatment center of the Order of the God of Nature.

"Brother Matthew!"

"Hey, little Gretel, why are you here free?"

Pastor Matthew turned his head from the alchemy table and greeted happily. Gretel was a little embarrassed: during this period, he really didn't go to the treatment center much. He was either busy with electrolysis or bacterial culture every day.

After the plague was discovered, people from the religious sect were brought in to help for a while, including treating patients, cultivating, staining, and microscopic examinations. It seems that the council hasn't calculated the treatment costs for them yet... I'm really sorry...

"Brother Matthew, I'm sorry, I was too busy a while ago." He walked up to the alchemy table and said, "Brother Matthew, what are you doing?"

"I'm making colchicum tablets... Don't tell me, the colchicine you made is really effective. Those guys with gout last time were cured after just a few days of taking the medicine. Oh, they are quite proud of themselves. They have been honest for two months. Just eat and drink like crazy, then come here to buy medicine, and then start tossing around again in two months!"

Colchicine tablets!

Gretel's eyes lit up. He seemed to grasp an idea, but also seemed not to grasp it. However, now is not the time to be distracted. Gretel rolled up his sleeves and stepped forward to help:

"Brother Matthew, let me help you do it together!"

Weigh, add alcohol, shake, filter and let stand. The alcohol was evaporated to obtain a crude extract of colchicine. The content has been measured last time, so there is no need to do it this time. In short, 20 grams of colchicum powder is used to make 12 tablets. Gretel was quick and smooth in doing the work. While doing it, she also reminded Pastor Matthew:

"Brother Matthew, remember to tell the patient that you can only take 1 to 2 tablets of this medicine every hour, and no more than 12 tablets per day, that is, 24 hours. If you take too much, you will be poisoned! It's true, colchicum is poisonous!"

"I know, I know! You told me that last time too!" Pastor Matthew laughed. "Really, you can cut a little colchicum powder and knead some starch to use it, but you insist on doing a lot of it like this!"

Gretel was stunned on the spot.

Yes, that's right. You can just eat medicinal plants directly - or the powder or juice of medicinal plants. Why do you need to make extracts? Why industrial production? Why should it be synthesized chemically?

Why do countless researchers in the fields of chemistry, chemical engineering, and biomedicine have to take this path despite all the difficulties and dangers they face and cause all kinds of trouble for themselves?

Not just for monopoly, not just for technical barriers. More importantly, the medication is safe!

For example, the dosage of colchicine is 0.5 to 1 mg every 1 to 2 hours for adults, and no more than 6 mg per day. If the dosage is too small, it will be useless; if the dosage is too large, it will be toxic. So, how to ensure the accuracy of dosage?

Control where colchicum comes from? This year's weather, sunshine, precipitation, fertilizer, will the colchicum grow well? Just the bulb, no leaves, or just certain parts of the bulb?

This kind of control method may be accurate to 0.1 grams or 0.01 grams. However, if you want to be accurate to milligrams or even micrograms, and if you want to make the dosage of each medication stable and uniform, you can't do it!

What about medicines with smaller single doses? For example, when fentanyl is used for anesthesia induction, the dosage is 0.05~0.1 mg...

Not to mention, the extracts of medicinal plants contain too many impurities. The simplest example is salicylic acid, the active ingredient in aspirin. Everyone knows that you can get it by boiling willow bark in water. But, how many ingredients are in willow bark tea?

Amino acids, sugars, organic acids, glycosides, phenols...

Dozens of species are rare. If you want to extract salicylic acid from it and eliminate the ineffective and harmful ingredients, hehe, I will cry to death.

This is why modern anesthesia medicine only came about after the emergence of modern chemistry. If it were ancient times, henbane, datura, belladonna and other herbs were mixed and extracted and then fed to patients, which was a complete gamble on their lives. If the raw material ingredients fluctuate slightly, the anesthesia will be excessive and the patient will not wake up...

Only by relying on chemistry, only by chemical extraction and refining, can the content of drugs be determined. Only by chemical synthesis can drugs with high purity, uniform and stable properties be made, and become a reliable helper for doctors!

These principles have all been learned before...

"Brother Matthew, thank you." Grete thanked him sincerely. Before Pastor Matthew could ask, Grete rushed out of the treatment center like a whirlwind and summoned his mount again. He rode around the street twice and stopped in front of a fruit stall:

"What's the price of these oranges? Where are the lemons? - I want them all, please help me deliver them!"

A cart of citrus, a basket of lemons, a cart of cabbage, and seven or eight other vegetables were dragged into Grete's villa one after another. The cook wiped her hands on her apron in surprise:

"Mr. Nodmark, are you...are you going to have a banquet?"

*****

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